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KMID : 0387820160230020158
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Clinical Pediatric Hematology-Oncology
2016 Volume.23 No. 2 p.158 ~ p.161
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Massive Fetomaternal Hemorrhage Diagnosed with High-performance Liquid Chromatography
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Lee Ji-Young
Kim Kyoung-Ha
Kong Seom-Gim
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Abstract
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Massive fetomaternal hemorrhage (FMH) is a major cause of unexplained fetal death and neonatal anemia. FMH can be diagnosed using the Kleihauer-Betke test or flow cytometry by identifying the presence of fetal red cells in the maternal blood. However, timely diagnosis is a challenge because many hospitals lack the equipment needed to perform such tests. The authors experienced a case of FMH diagnosed via high-performance liquid chromatography (HPLC) which is generally used in measuring glycated hemoglobin (HbA1c) in a patient with unexplained neonatal anemia. A girl aged 2 days was transferred to our hospital for showing pallor and a hemoglobin level of 5.0 g/dL. HPLC revealed 3% fetal hemoglobin (HbF) in the maternal blood. HPLC is a quick test for quantifying HbF that is readily available in many hospitals and could serve as a promising alternative for diagnosing FMH.
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KEYWORD
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Fetomaternal hemorrhage, HPLC, Fetal hemoglobin
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